Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug–drug interactions

BACKGROUND: Kang-Ai injection is widely used as an adjuvant therapy drug for many cancers, leukopenia, and chronic hepatitis B. Circulating alkaloids and saponins are believed to be responsible for therapeutic effects. However, their pharmacokinetics (PK) and excretion in vivo and the risk of drug–d...

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Detalles Bibliográficos
Autores principales: Qin, Zifei, Jia, Mengmeng, Yang, Jing, Xing, Han, Yin, Zhao, Yao, Zhihong, Zhang, Xiaojian, Yao, Xinsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339578/
https://www.ncbi.nlm.nih.gov/pubmed/32655683
http://dx.doi.org/10.1186/s13020-020-00349-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339578/
https://www.ncbi.nlm.nih.gov/pubmed/32655683
http://dx.doi.org/10.1186/s13020-020-00349-3

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