Cargando…

SAMHD1 expression is associated with low immune activation but not correlated with HIV-1 DNA levels in CD4(+) T cells of patients with HIV-1

Sterile α motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) can inhibit reverse transcription of human immunodeficiency virus-1 (HIV-1) by hydrolyzing intracellular deoxy-ribonucleoside triphosphate. However, its role in HIV-1 disease progression has not been extensively studied...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jie, Gao, Chuanhua, Huang, Shanshan, Jin, Longteng, Jin, Changzhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339818/ https://www.ncbi.nlm.nih.gov/pubmed/32468062 http://dx.doi.org/10.3892/mmr.2020.11153

Ejemplares similares

Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection
por: Fu, Weihui, et al.
Publicado: (2016)

Proliferative memory SAMHD1(low) CD4(+) T cells harbour high levels of HIV-1 with compartmentalized viral populations
por: Hani, Lylia, et al.
Publicado: (2019)

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells
por: Descours, Benjamin, et al.
Publicado: (2012)

CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels
por: Rocha-Perugini, Vera, et al.
Publicado: (2017)

Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1
por: Brandariz-Nuñez, Alberto, et al.
Publicado: (2013)

SAMHD1: a new contributor to HIV-1 restriction in resting CD4(+) T-cells
por: Wu, Li
Publicado: (2012)

Low SAMHD1 expression following T-cell activation and proliferation renders CD4(+) T cells susceptible to HIV-1
por: Ruffin, Nicolas, et al.
Publicado: (2015)

DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1
por: Jáuregui, Paula, et al.
Publicado: (2018)

Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac
por: Brandariz-Nuñez, Alberto, et al.
Publicado: (2012)

Vpx enhances innate immune responses independently of SAMHD1 during HIV-1 infection
por: Cingöz, Oya, et al.
Publicado: (2021)

DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV‐1 infection of macrophages
por: Mlcochova, Petra, et al.
Publicado: (2017)

SAMHD1: a new insight into HIV-1 restriction in myeloid cells
por: St Gelais, Corine, et al.
Publicado: (2011)

The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral Response
por: Antonucci, Jenna M., et al.
Publicado: (2017)

Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection
por: Plitnik, Timothy, et al.
Publicado: (2018)

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels
por: Schüssler, Moritz, et al.
Publicado: (2023)

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels
por: Schüssler, Moritz, et al.
Publicado: (2023)

Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection
por: Yan, Junpeng, et al.
Publicado: (2013)

Pharmacological Targeting of Sphingosine Kinases Impedes HIV-1 Infection of CD4 T Cells through SAMHD1 Modulation
por: Resop, Rachel S., et al.
Publicado: (2022)

Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1
por: Maelfait, Jonathan, et al.
Publicado: (2016)

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
por: Hrecka, Kasia, et al.
Publicado: (2011)

SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells
por: Ordonez, Paula, et al.
Publicado: (2017)

Binding to DCAF1 distinguishes TASOR and SAMHD1 degradation by HIV-2 Vpx
por: Martin, Michaël M., et al.
Publicado: (2021)

Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells
por: Tsai, Ming-Han C., et al.
Publicado: (2023)

SAMHD1-Deficient CD14+ Cells from Individuals with Aicardi-Goutières Syndrome Are Highly Susceptible to HIV-1 Infection
por: Berger, André, et al.
Publicado: (2011)

IL-7 Induces SAMHD1 Phosphorylation in CD4+ T Lymphocytes, Improving Early Steps of HIV-1 Life Cycle
por: Coiras, Mayte, et al.
Publicado: (2016)

SAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx Protein
por: Fujita, Mikako, et al.
Publicado: (2012)

Evidence that HIV-1 restriction factor SAMHD1 facilitates differentiation of myeloid THP-1 cells
por: Dragin, Loic, et al.
Publicado: (2015)

A G1‐like state allows HIV‐1 to bypass SAMHD1 restriction in macrophages
por: Mlcochova, Petra, et al.
Publicado: (2017)

Evidence for IFNα-induced, SAMHD1-independent inhibitors of early HIV-1 infection
por: Goujon, Caroline, et al.
Publicado: (2013)

SAMHD1 Restricts HIV-1 Replication and Regulates Interferon Production in Mouse Myeloid Cells
por: Zhang, Ruonan, et al.
Publicado: (2014)

Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages
por: Mahboubi, Bijan, et al.
Publicado: (2018)

Cell-to-Cell Spreading of HIV-1 in Myeloid Target Cells Escapes SAMHD1 Restriction
por: Xie, Maorong, et al.
Publicado: (2019)

SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
por: Martinat, Charlotte, et al.
Publicado: (2021)

miRNAs and SAMHD1 regulation in vitro and in a model of HIV CNS disease
por: Witwer, Kenneth W., et al.
Publicado: (2015)

The role of SAMHD1 expression and its relation to HIV-2 (Vpx) gene production
por: Bakir, Talal M.
Publicado: (2018)

A Continuous Enzyme-Coupled Assay for Triphosphohydrolase Activity of HIV-1 Restriction Factor SAMHD1
por: Arnold, Laurence H., et al.
Publicado: (2014)

SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition
por: Szaniawski, Matthew A., et al.
Publicado: (2018)

The efficiency of Vpx-mediated SAMHD1 antagonism does not correlate with the potency of viral control in HIV-2-infected individuals
por: Yu, Hangxing, et al.
Publicado: (2013)

Substrates and Inhibitors of SAMHD1
por: Hollenbaugh, Joseph A., et al.
Publicado: (2017)

SAMHD1 expression modulates innate immune activation and correlates with ovarian cancer prognosis
por: Gutiérrez-Chamorro, Lucía, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_icerm85ibmb3u1uo36p6fn80eq