Deep Mutational Scanning Reveals the Structural Basis for α-Synuclein Activity

Defining the biologically active structures of proteins in their cellular environments remains challenging for proteins with multiple conformations and functions, where only a minor conformer might be associated with a given function. Here, we use deep mutational scanning to probe the structure and...

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Detalles Bibliográficos
Autores principales: Newberry, Robert W., Leong, Jaime T., Chow, Eric D., Kampmann, Martin, DeGrado, William F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339969/
https://www.ncbi.nlm.nih.gov/pubmed/32152544
http://dx.doi.org/10.1038/s41589-020-0480-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339969/
https://www.ncbi.nlm.nih.gov/pubmed/32152544
http://dx.doi.org/10.1038/s41589-020-0480-6

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