Cargando…
Inhibition of M/K(v)7 Currents Contributes to Chloroquine-Induced Itch in Mice
M/K(v)7 potassium channels play a key role in regulation of neuronal excitability. Modulation of neuronal excitability of primary sensory neurons determines the itch sensation induced by a variety of itch-causing substances including chloroquine (CQ). In the present study, we demonstrate that suppre...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339983/ https://www.ncbi.nlm.nih.gov/pubmed/32694980 http://dx.doi.org/10.3389/fnmol.2020.00105 |
_version_ | 1783554970066354176 |
---|---|
author | Zhang, Dong Men, Hongchao Zhang, Ludi Gao, Xiangxin Wang, Jingjing Li, Leying Zhu, Qiaoying Zhang, Hailin Jia, Zhanfeng |
author_facet | Zhang, Dong Men, Hongchao Zhang, Ludi Gao, Xiangxin Wang, Jingjing Li, Leying Zhu, Qiaoying Zhang, Hailin Jia, Zhanfeng |
author_sort | Zhang, Dong |
collection | PubMed |
description | M/K(v)7 potassium channels play a key role in regulation of neuronal excitability. Modulation of neuronal excitability of primary sensory neurons determines the itch sensation induced by a variety of itch-causing substances including chloroquine (CQ). In the present study, we demonstrate that suppression of M/K(v)7 channel activity contributes to generation of itch in mice. CQ enhances excitability of the primary sensory neurons through inhibiting M/K(v)7 potassium currents in a Ca(2+) influx-dependent manner. Specific M/K(v)7 channel opener retigabine (RTG) or tannic acid (TA) not only reverses the CQ-induced enhancement of neuronal excitability but also suppresses the CQ-induced itch behavior. Systemic application of RTG or TA also significantly inhibits the itch behavior induced by a variety of pruritogens. Taken together, our findings provide novel insight into the molecular basis of CQ-induced itch sensation in mammals that can be applied to the development of strategies to mitigate itch behavior. |
format | Online Article Text |
id | pubmed-7339983 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73399832020-07-20 Inhibition of M/K(v)7 Currents Contributes to Chloroquine-Induced Itch in Mice Zhang, Dong Men, Hongchao Zhang, Ludi Gao, Xiangxin Wang, Jingjing Li, Leying Zhu, Qiaoying Zhang, Hailin Jia, Zhanfeng Front Mol Neurosci Neuroscience M/K(v)7 potassium channels play a key role in regulation of neuronal excitability. Modulation of neuronal excitability of primary sensory neurons determines the itch sensation induced by a variety of itch-causing substances including chloroquine (CQ). In the present study, we demonstrate that suppression of M/K(v)7 channel activity contributes to generation of itch in mice. CQ enhances excitability of the primary sensory neurons through inhibiting M/K(v)7 potassium currents in a Ca(2+) influx-dependent manner. Specific M/K(v)7 channel opener retigabine (RTG) or tannic acid (TA) not only reverses the CQ-induced enhancement of neuronal excitability but also suppresses the CQ-induced itch behavior. Systemic application of RTG or TA also significantly inhibits the itch behavior induced by a variety of pruritogens. Taken together, our findings provide novel insight into the molecular basis of CQ-induced itch sensation in mammals that can be applied to the development of strategies to mitigate itch behavior. Frontiers Media S.A. 2020-06-30 /pmc/articles/PMC7339983/ /pubmed/32694980 http://dx.doi.org/10.3389/fnmol.2020.00105 Text en Copyright © 2020 Zhang, Men, Zhang, Gao, Wang, Li, Zhu, Zhang and Jia. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhang, Dong Men, Hongchao Zhang, Ludi Gao, Xiangxin Wang, Jingjing Li, Leying Zhu, Qiaoying Zhang, Hailin Jia, Zhanfeng Inhibition of M/K(v)7 Currents Contributes to Chloroquine-Induced Itch in Mice |
title | Inhibition of M/K(v)7 Currents Contributes to Chloroquine-Induced Itch in Mice |
title_full | Inhibition of M/K(v)7 Currents Contributes to Chloroquine-Induced Itch in Mice |
title_fullStr | Inhibition of M/K(v)7 Currents Contributes to Chloroquine-Induced Itch in Mice |
title_full_unstemmed | Inhibition of M/K(v)7 Currents Contributes to Chloroquine-Induced Itch in Mice |
title_short | Inhibition of M/K(v)7 Currents Contributes to Chloroquine-Induced Itch in Mice |
title_sort | inhibition of m/k(v)7 currents contributes to chloroquine-induced itch in mice |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339983/ https://www.ncbi.nlm.nih.gov/pubmed/32694980 http://dx.doi.org/10.3389/fnmol.2020.00105 |
work_keys_str_mv | AT zhangdong inhibitionofmkv7currentscontributestochloroquineinduceditchinmice AT menhongchao inhibitionofmkv7currentscontributestochloroquineinduceditchinmice AT zhangludi inhibitionofmkv7currentscontributestochloroquineinduceditchinmice AT gaoxiangxin inhibitionofmkv7currentscontributestochloroquineinduceditchinmice AT wangjingjing inhibitionofmkv7currentscontributestochloroquineinduceditchinmice AT lileying inhibitionofmkv7currentscontributestochloroquineinduceditchinmice AT zhuqiaoying inhibitionofmkv7currentscontributestochloroquineinduceditchinmice AT zhanghailin inhibitionofmkv7currentscontributestochloroquineinduceditchinmice AT jiazhanfeng inhibitionofmkv7currentscontributestochloroquineinduceditchinmice |