Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation

Exhaustion is a dysfunctional state of cytotoxic CD8+ T cells (CTL) observed in chronic infection and cancer. Current in vivo models of CTL exhaustion using chronic viral infections or cancer yield very few exhausted CTL, limiting the analysis that can be done on these cells. Establishing an in vitr...

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Detalles Bibliográficos
Autores principales: Zhao, Manzhi, Kiernan, Caoimhe H., Stairiker, Christopher J., Hope, Jennifer L., Leon, Leticia G., van Meurs, Marjan, Brouwers-Haspels, Inge, Boers, Ruben, Boers, Joachim, Gribnau, Joost, van IJcken, Wilfred F. J., Bindels, Eric M., Hoogenboezem, Remco M., Erkeland, Stefan J., Mueller, Yvonne M., Katsikis, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340326/
https://www.ncbi.nlm.nih.gov/pubmed/32579593
http://dx.doi.org/10.1371/journal.ppat.1008555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340326/
https://www.ncbi.nlm.nih.gov/pubmed/32579593
http://dx.doi.org/10.1371/journal.ppat.1008555

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