Synaptic Loss, ER Stress and Neuro-Inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer’s Disease

The complex multifactorial nature of AD pathogenesis has been highlighted by evidence implicating additional neurodegenerative mechanisms, beyond that of amyloid-β (Aβ) and tau. To provide insight into cause and effect, we here investigated the temporal profile and associations of pathological chang...

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Detalles Bibliográficos
Autores principales: Buchanan, Heather, Mackay, Murray, Palmer, Kerri, Tothová, Karolína, Katsur, Miroslava, Platt, Bettina, Koss, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340653/
https://www.ncbi.nlm.nih.gov/pubmed/32514860
http://dx.doi.org/10.1007/s12035-020-01950-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340653/
https://www.ncbi.nlm.nih.gov/pubmed/32514860
http://dx.doi.org/10.1007/s12035-020-01950-1

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