Calbindin Deficits May Underlie Dissociable Effects of 5-HT(6) and mGlu(7) Antagonists on Glutamate and Cognition in a Dual-Hit Neurodevelopmental Model for Schizophrenia

Despite several compounds entering clinical trials for the negative and cognitive symptoms of schizophrenia, few have progressed beyond phase III. This is partly attributed to a need for improved preclinical models, to understand disease and enable predictive evaluation of novel therapeutics. To thi...

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Detalles Bibliográficos
Autores principales: Shortall, Sinead E., Brown, Angus M., Newton-Mann, Eliot, Dawe-Lane, Erin, Evans, Chanelle, Fowler, Maxine, King, Madeleine V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340678/
https://www.ncbi.nlm.nih.gov/pubmed/32533466
http://dx.doi.org/10.1007/s12035-020-01938-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340678/
https://www.ncbi.nlm.nih.gov/pubmed/32533466
http://dx.doi.org/10.1007/s12035-020-01938-x

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