Non-signaling Chimeric Antigen Receptors Enhance Antigen-Directed Killing by γδ T Cells in Contrast to αβ T Cells

Chimeric antigen receptor (CAR)-modified T cells have demonstrated efficacy against B cell leukemias/lymphomas. However, redirecting CAR T cells to malignant T cells is more challenging due to product-specific cis- and trans-activation causing fratricide. Other challenges include the potential for p...

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Detalles Bibliográficos
Autores principales: Fleischer, Lauren C., Becker, Scott A., Ryan, Rebecca E., Fedanov, Andrew, Doering, Christopher B., Spencer, H. Trent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341062/
https://www.ncbi.nlm.nih.gov/pubmed/32671190
http://dx.doi.org/10.1016/j.omto.2020.06.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341062/
https://www.ncbi.nlm.nih.gov/pubmed/32671190
http://dx.doi.org/10.1016/j.omto.2020.06.003

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