MLH1 Deficiency Induces Cetuximab Resistance in Colon Cancer via Her‐2/PI3K/AKT Signaling

The rapid onset of resistance to cetuximab (CTX) limits its clinical utility in colorectal cancer (CRC) patients. This study aims to understand a potential role of mismatch repair gene mutL homolog 1 (MLH1) in CTX response. Functional analysis of MLH1 in Her‐2/phosphoinositide 3‐kinases (PI3K)/PKB p...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Ying, Peng, Yinghui, Fu, Yaojie, Cai, Changjing, Guo, Cao, Liu, Shanshan, Li, Yiyi, Chen, Yihong, Shen, Edward, Long, Kexin, Wang, Xinwen, Yu, Jian, Shen, Hong, Zeng, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341094/
https://www.ncbi.nlm.nih.gov/pubmed/32670759
http://dx.doi.org/10.1002/advs.202000112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341094/
https://www.ncbi.nlm.nih.gov/pubmed/32670759
http://dx.doi.org/10.1002/advs.202000112

Ejemplares similares