WRN inhibits oxidative stress-induced apoptosis of human lensepithelial cells through ATM/p53 signaling pathway and its expression is downregulated by DNA methylation

BACKGROUND: Apoptosis and oxidative stress are the main etiology of age related cataract (ARC). This article aims to investigate the role of WRN in lens epithelial cells (LECs). METHODS: We estimated the methylation level of WRN in anterior lens capsule tissues of ARC patients. SRA01/04 (LECs) cells...

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Detalles Bibliográficos
Autores principales: Jiang, Shengqun, Chen, Jiansu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341633/
https://www.ncbi.nlm.nih.gov/pubmed/32640976
http://dx.doi.org/10.1186/s10020-020-00187-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341633/
https://www.ncbi.nlm.nih.gov/pubmed/32640976
http://dx.doi.org/10.1186/s10020-020-00187-x

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