The proofreading activity of Pfprex from Plasmodium falciparum can prevent mutagenesis of the apicoplast genome by oxidized nucleotides

The DNA polymerase module of the Pfprex enzyme (PfpPol) is responsible for duplication of the genome of the apicoplast organelle in the malaria parasite. We show that PfpPol can misincorporate oxidized nucleotides such as 8oxodGTP opposite dA. This event gives rise to transversion mutations that are...

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Detalles Bibliográficos
Autores principales: Sharma, Minakshi, Narayanan, Naveen, Nair, Deepak T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341739/
https://www.ncbi.nlm.nih.gov/pubmed/32636411
http://dx.doi.org/10.1038/s41598-020-67853-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341739/
https://www.ncbi.nlm.nih.gov/pubmed/32636411
http://dx.doi.org/10.1038/s41598-020-67853-2

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