A physics-based energy function allows the computational redesign of a PDZ domain

Computational protein design (CPD) can address the inverse folding problem, exploring a large space of sequences and selecting ones predicted to fold. CPD was used previously to redesign several proteins, employing a knowledge-based energy function for both the folded and unfolded states. We show th...

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Detalles Bibliográficos
Autores principales: Opuu, Vaitea, Sun, Young Joo, Hou, Titus, Panel, Nicolas, Fuentes, Ernesto J., Simonson, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341745/
https://www.ncbi.nlm.nih.gov/pubmed/32636412
http://dx.doi.org/10.1038/s41598-020-67972-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341745/
https://www.ncbi.nlm.nih.gov/pubmed/32636412
http://dx.doi.org/10.1038/s41598-020-67972-w

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