The aptamer BT200 effectively inhibits von Willebrand factor (VWF) dependent platelet function after stimulated VWF release by desmopressin or endotoxin

Von Willebrand factor (VWF) plays a major role in arterial thrombosis. Antiplatelet drugs induce only a moderate relative risk reduction after atherothrombosis, and their inhibitory effects are compromised under high shear rates when VWF levels are increased. Therefore, we investigated the ex vivo e...

Descripción completa

Detalles Bibliográficos
Autores principales: Kovacevic, Katarina D., Buchtele, Nina, Schoergenhofer, Christian, Derhaschnig, Ulla, Gelbenegger, Georg, Brostjan, Christine, Zhu, Shuhao, Gilbert, James C., Jilma, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341806/
https://www.ncbi.nlm.nih.gov/pubmed/32636459
http://dx.doi.org/10.1038/s41598-020-68125-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341806/
https://www.ncbi.nlm.nih.gov/pubmed/32636459
http://dx.doi.org/10.1038/s41598-020-68125-9

Ejemplares similares