A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function

Regulatory T (Treg) cells play a pivotal role in suppressing auto-reactive T cells and maintaining immune homeostasis. Treg cell development and function are dependent on the transcription factor Foxp3. Here, we performed a genome-wide CRISPR loss-of-function screen to identify Foxp3 regulators in m...

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Detalles Bibliográficos
Autores principales: Loo, Chin-San, Gatchalian, Jovylyn, Liang, Yuqiong, Leblanc, Mathias, Xie, Mingjun, Ho, Josephine, Venkatraghavan, Bhargav, Hargreaves, Diana C., Zheng, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341821/
https://www.ncbi.nlm.nih.gov/pubmed/32640256
http://dx.doi.org/10.1016/j.immuni.2020.06.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341821/
https://www.ncbi.nlm.nih.gov/pubmed/32640256
http://dx.doi.org/10.1016/j.immuni.2020.06.011

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