Humanized GPRC6A(KGKY) is a gain-of-function polymorphism in mice

GPRC6A is proposed to regulate energy metabolism in mice, but in humans a KGKY polymorphism in the third intracellular loop (ICL3) is proposed to result in intracellular retention and loss-of-function. To test physiological importance of this human polymorphism in vivo, we performed targeted genomic...

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Detalles Bibliográficos
Autores principales: Pi, Min, Xu, Fuyi, Ye, Ruisong, Nishimoto, Satoru K., Kesterson, Robert A., Williams, Robert W., Lu, Lu, Quarles, L. Darryl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341878/
https://www.ncbi.nlm.nih.gov/pubmed/32636482
http://dx.doi.org/10.1038/s41598-020-68113-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341878/
https://www.ncbi.nlm.nih.gov/pubmed/32636482
http://dx.doi.org/10.1038/s41598-020-68113-z

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