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利用MigR1质粒构建CD19-CAR逆转录病毒载体优化其对人原代T细胞的转染效率
OBJECTIVE: To improve the MigR1-CD19-CAR (chimeric antigen receptor) that contains a single chain variable region (scFv) which targeted to CD19 through a retroviral vector transduction efficiency of T-lymphocytes. METHODS: Insert the CD19-CAR fragment into the retroviral vector (MigR1) through recom...
| Formato: | Online Artículo Texto |
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| Lenguaje: | English |
| Publicado: |
Editorial office of Chinese Journal of Hematology
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342607/ https://www.ncbi.nlm.nih.gov/pubmed/25916298 http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2015.04.016 |