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一种新的高亲和力的人源化抗CD19 CAR-T细胞的构建及体外功能验证
OBJECTIVE: To construct humanized anti-CD19 chimeric antigen receptor T cells and investigate its ability to kill leukemia cells in vitro and in vivo. METHODS: Humanized anti-human CD19 antibody with a high affinity was obtained based on mouse anti-human CD19 antibody (FMC63). Humanized CD19 CAR-T c...
| Formato: | Online Artículo Texto |
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| Lenguaje: | English |
| Publicado: |
Editorial office of Chinese Journal of Hematology
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342930/ https://www.ncbi.nlm.nih.gov/pubmed/30032561 http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2018.06.005 |