Cargando…
Mechanobiological model for simulation of injured cartilage degradation via pro-inflammatory cytokines and mechanical stimulus
Post-traumatic osteoarthritis (PTOA) is associated with cartilage degradation, ultimately leading to disability and decrease of quality of life. Two key mechanisms have been suggested to occur in PTOA: tissue inflammation and abnormal biomechanical loading. Both mechanisms have been suggested to res...
Autores principales: | Eskelinen, Atte S. A., Tanska, Petri, Florea, Cristina, Orozco, Gustavo A., Julkunen, Petro, Grodzinsky, Alan J., Korhonen, Rami K. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343184/ https://www.ncbi.nlm.nih.gov/pubmed/32584809 http://dx.doi.org/10.1371/journal.pcbi.1007998 |
Ejemplares similares
-
A novel mechanobiological model can predict how physiologically relevant dynamic loading causes proteoglycan loss in mechanically injured articular cartilage
por: Orozco, Gustavo A., et al.
Publicado: (2018) -
Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines
por: Kosonen, Joonas P., et al.
Publicado: (2023) -
Superficial Collagen Fibril Modulus and Pericellular Fixed Charge Density Modulate Chondrocyte Volumetric Behaviour in Early Osteoarthritis
por: Tanska, Petri, et al.
Publicado: (2013) -
Computational Models of Articular Cartilage
por: Korhonen, Rami K., et al.
Publicado: (2013) -
An in silico Framework of Cartilage Degeneration That Integrates Fibril Reorientation and Degradation Along With Altered Hydration and Fixed Charge Density Loss
por: Elahi, Seyed Ali, et al.
Publicado: (2021)