Cargando…

Endothelin-1 induces cellular senescence and fibrosis in cultured myoblasts. A potential mechanism of aging-related sarcopenia

Endothelial dysfunction, with increased endothelin-1 (ET-1) synthesis, and sarcopenia, characterized by the loss of muscular mass and strength, are two aging–related conditions. However, a relationship between them has not been already established. The aim of this study was to determine whether ET-1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alcalde-Estévez, Elena, Asenjo-Bueno, Ana, Sosa, Patricia, Olmos, Gemma, Plaza, Patricia, Caballero-Mora, María Ángeles, Rodríguez-Puyol, Diego, Ruíz-Torres, María Piedad, López-Ongil, Susana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343454/ https://www.ncbi.nlm.nih.gov/pubmed/32572011 http://dx.doi.org/10.18632/aging.103450

Ejemplares similares

Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia
por: Sosa, Patricia, et al.
Publicado: (2018)

Uraemic toxins impair skeletal muscle regeneration by inhibiting myoblast proliferation, reducing myogenic differentiation, and promoting muscular fibrosis
por: Alcalde-Estévez, Elena, et al.
Publicado: (2021)

Hyperphosphatemia induces senescence in human endothelial cells by increasing endothelin‐1 production
por: Olmos, Gemma, et al.
Publicado: (2017)

Dietary phosphate restriction prevents the appearance of sarcopenia signs in old mice
por: Alcalde‐Estévez, Elena, et al.
Publicado: (2023)

Aging‐related hyperphosphatemia impairs myogenic differentiation and enhances fibrosis in skeletal muscle
por: Sosa, Patricia, et al.
Publicado: (2021)

Hyperphosphatemia-Induced Oxidant/Antioxidant Imbalance Impairs Vascular Relaxation and Induces Inflammation and Fibrosis in Old Mice
por: Asenjo-Bueno, Ana, et al.
Publicado: (2021)

Glucose Oxidase Induces Cellular Senescence in Immortal Renal Cells through ILK by Downregulating Klotho Gene Expression
por: Troyano-Suárez, Nuria, et al.
Publicado: (2015)

Corrigendum to “Glucose Oxidase Induces Cellular Senescence in Immortal Renal Cells through ILK by Downregulating Klotho Gene Expression”
por: Troyano-Suárez, Nuria, et al.
Publicado: (2016)

SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3
por: Tripathi, Utkarsh, et al.
Publicado: (2021)

GRSF1 suppresses cell senescence
por: Noh, Ji Heon, et al.
Publicado: (2018)

Acid ceramidase promotes senescent cell survival
por: Munk, Rachel, et al.
Publicado: (2021)

Comparison of SARS-CoV-2 RT-PCR on a high-throughput molecular diagnostic platform and the cobas SARS-CoV-2 test for the diagnostic of COVID-19 on various clinical samples
por: Opota, Onya, et al.
Publicado: (2020)

Cdkn1a transcript variant 2 is a marker of aging and cellular senescence
por: López-Domínguez, José Alberto, et al.
Publicado: (2021)

Survey of senescent cell markers with age in human tissues
por: Idda, M. Laura, et al.
Publicado: (2020)

Senescence-associated hyper-activation to inflammatory stimuli in vitro
por: Budamagunta, Vivekananda, et al.
Publicado: (2021)

Senescence-associated tumor growth is promoted by 12-Lipoxygenase
por: Patil, Shilpa, et al.
Publicado: (2022)

Gene expression signatures of human senescent corneal and conjunctival epithelial cells
por: Kitazawa, Koji, et al.
Publicado: (2023)

Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes
por: Schwartz, Rachael E., et al.
Publicado: (2021)

Impaired erythropoietin synthesis in chronic kidney disease is caused by alterations in extracellular matrix composition
por: Olmos, Gemma, et al.
Publicado: (2017)

c-Myb and C/EBPβ regulate OPN and other senescence-associated secretory phenotype factors
por: Flanagan, Kevin C., et al.
Publicado: (2017)

Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging
por: Li, Tongyuan, et al.
Publicado: (2016)

Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression
por: Lee, Ok-Hee, et al.
Publicado: (2020)

AMP-activated protein kinase-dependent nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in senescent human diploid fibroblasts
por: Sohn, Jee Young, et al.
Publicado: (2022)

Senescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractility
por: Aifuwa, Ivie, et al.
Publicado: (2015)

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging
por: Zhao, Jing, et al.
Publicado: (2020)

p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia
por: Yetil, Alper, et al.
Publicado: (2015)

Current understanding on the neurophysiology of behavioral thermoregulation
por: Almeida, Maria Camila, et al.
Publicado: (2015)

Temperature and toxic Tau in Alzheimer's disease: new insights
por: Carrettiero, Daniel Carneiro, et al.
Publicado: (2015)

The relationship of NM23 (NME) metastasis suppressor histidine phosphorylation to its nucleoside diphosphate kinase, histidine protein kinase and motility suppression activities
por: Khan, Imran, et al.
Publicado: (2017)

Cell immortalization facilitates prelamin A clearance by increasing both cell proliferation and autophagic flux
por: González-Blanco, Carlos, et al.
Publicado: (2022)

Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer
por: Iskit, Sedef, et al.
Publicado: (2016)

Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors
por: Liu, Qinghai, et al.
Publicado: (2009)

Peripheral Inflammation is Associated with Altered Substantia Nigra Activity and Psychomotor Slowing in Humans
por: Brydon, Lena, et al.
Publicado: (2008)

Chronic Activation of Corticotropin-Releasing Factor Type 2 Receptors Reveals a Key Role for 5-HT1A Receptor Responsiveness in Mediating Behavioral and Serotonergic Responses to Stressful Challenge
por: Neufeld-Cohen, Adi, et al.
Publicado: (2012)

Hostility and Cellular Aging in Men from the Whitehall II Cohort
por: Brydon, Lena, et al.
Publicado: (2012)

Regulation of Bim in Health and Disease
por: Sionov, Ronit Vogt, et al.
Publicado: (2015)

Urinary thrombomodulin and catecholamine levels are interrelated in healthy volunteers immersed in cold and warm water
por: Pakanen, Lasse, et al.
Publicado: (2015)

Arterio-venous anastomoses in the human skin and their role in temperature control
por: Walløe, Lars
Publicado: (2015)

High intensity interval training in the heat enhances exercise-induced lipid peroxidation, but prevents protein oxidation in physically active men
por: Souza-Silva, Ana Angélica, et al.
Publicado: (2015)

Human whole body cold adaptation
por: Daanen, Hein A.M., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_i6tvu5auvinm4e5mihjts48mud