Cargando…

Long noncoding RNA KCNQ1OT1 promotes colorectal carcinogenesis by enhancing aerobic glycolysis via hexokinase-2

In this study, we investigated the mechanistic role and prognostic significance of the long coding RNA (lncRNA) KCNQ1OT1 in colorectal cancer (CRC). KCNQ1OT1 levels were significantly higher in CRC tissues than adjacent normal colorectal tissues (n=79). High KCNQ1OT1 expression correlated with poore...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Cheng, Wei, Meng, Wang, Chao, Sun, Danping, Liu, Peng, Zhong, Xin, Yu, Wenbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343465/ https://www.ncbi.nlm.nih.gov/pubmed/32564010 http://dx.doi.org/10.18632/aging.103334

Ejemplares similares

KCNQ1OT1: An Oncogenic Long Noncoding RNA
por: Cagle, Patrice, et al.
Publicado: (2021)

Regulation of Long Non-coding RNA KCNQ1OT1 Network in Colorectal Cancer Immunity
por: Liu, Junjie, et al.
Publicado: (2021)

LncRNA KCNQ1OT1 sponges miR-34c-5p to promote osteosarcoma growth via ALDOA enhanced aerobic glycolysis
por: Shen, Yifei, et al.
Publicado: (2020)

KCNQ1OT1 polymorphism rs35622507 and methylation status of KCNQ1OT1 promoter influence the drug resistance to L-OHP
por: Zhang, Caihong, et al.
Publicado: (2022)

KCNQ1OT1 promotes melanoma growth and metastasis
por: Guo, Bingyu, et al.
Publicado: (2018)

Long Noncoding RNA KCNQ1OT1 is a Prognostic Biomarker and mediates CD8(+) T cell exhaustion by regulating CD155 Expression in Colorectal Cancer
por: Lin, Zheng-bin, et al.
Publicado: (2021)

Cyclin D1 targets hexokinase 2 to control aerobic glycolysis in myeloma cells
por: Caillot, M., et al.
Publicado: (2020)

Long noncoding RNA KCNQ1OT1 promotes proliferation and epithelial-mesenchymal transition by regulation of SMAD4 expression in lens epithelial cells
por: Chen, Bin, et al.
Publicado: (2018)

Long Noncoding RNA KCNQ1OT1 Accelerates the Progression of Ovarian Cancer via MicroRNA-212-3/LCN2 Axis
por: Lu, Xiaoqin, et al.
Publicado: (2020)

Long noncoding RNA KCNQ1OT1 inhibits osteoclast differentiation by regulating the miR-128-3p/NFAT5 axis
por: Zhang, Hengshuo, et al.
Publicado: (2022)

Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma
por: Gershon, Timothy R, et al.
Publicado: (2013)

Regulation of functional KCNQ1OT1 lncRNA by β-catenin
por: Sunamura, Naohiro, et al.
Publicado: (2016)

Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis
por: Liu, Wenbin, et al.
Publicado: (2019)

Sinomenine Inhibits Non-Small Cell Lung Cancer via Downregulation of Hexokinases II-Mediated Aerobic Glycolysis
por: Liu, Wenbin, et al.
Publicado: (2020)

DNA Methylation of Imprinted Genes KCNQ1, KCNQ1OT1, and PHLDA2 in Peripheral Blood Is Associated with the Risk of Breast Cancer
por: Fu, Jinming, et al.
Publicado: (2022)

The Kcnq1ot1 Long Non-Coding RNA Affects Chromatin Conformation and Expression of Kcnq1, but Does Not Regulate Its Imprinting in the Developing Heart
por: Korostowski, Lisa, et al.
Publicado: (2012)

Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy
por: Yang, Fan, et al.
Publicado: (2018)

PNN and KCNQ1OT1 Can Predict the Efficacy of Adjuvant Fluoropyrimidine-Based Chemotherapy in Colorectal Cancer Patients
por: Lapucci, Andrea, et al.
Publicado: (2021)

BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells
por: An, Ming-Xin, et al.
Publicado: (2017)

Long Noncoding RNA KCNQ1OT1 Promotes the Progression of Non-Small Cell Lung Cancer via Regulating miR-204-5p/ATG3 Axis
por: Kang, Yan, et al.
Publicado: (2019)

Long noncoding RNA Kcnq1ot1 prompts lipopolysaccharide-induced acute lung injury by microRNA-7a-5p/Rtn3 axis
por: Yang, Shuo, et al.
Publicado: (2022)

Knockdown of KCNQ1OT1 Suppresses Cell Invasion and Sensitizes Osteosarcoma Cells to CDDP by Upregulating DNMT1-Mediated Kcnq1 Expression
por: Qi, Xu, et al.
Publicado: (2019)

LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases
por: Xia, Fangqi, et al.
Publicado: (2021)

Retraction: Long non-coding RNA KCNQ1OT1 promotes osteosarcoma progression by increasing β-catenin activity
por: Fisher, Laura
Publicado: (2021)

Silencing of KCNQ1OT1 Decreases Oxidative Stress and Pyroptosis of Renal Tubular Epithelial Cells
por: Zhu, Bei, et al.
Publicado: (2020)

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
por: Wolf, Amparo, et al.
Publicado: (2011)

Inhibition of hexokinase-2 with targeted liposomal 3-bromopyruvate in an ovarian tumor spheroid model of aerobic glycolysis
por: Gandham, Srujan Kumar, et al.
Publicado: (2015)

Retraction Notice to: Knockdown of KCNQ1OT1 Suppresses Cell Invasion and Sensitizes Osteosarcoma Cells to CDDP by Upregulating DNMT1-Mediated Kcnq1 Expression
por: Qi, Xu, et al.
Publicado: (2022)

Retracted Article: Long non-coding RNA KCNQ1OT1 promotes osteosarcoma progression by increasing β-catenin activity
por: Zhang, Changsheng, et al.
Publicado: (2018)

Sequence variants identification at the KCNQ1OT1:TSS differentially Methylated region in isolated omphalocele cases
por: Bedeschi, Maria Francesca, et al.
Publicado: (2017)

LncRNA KCNQ1OT1 predicts further cerebral events in patients with transient ischemic attack
por: Yu, Shijia, et al.
Publicado: (2022)

Long non-coding RNA KCNQ1OT1 mediates the growth of hepatocellular carcinoma by functioning as a competing endogenous RNA of miR-504
por: Li, Chao, et al.
Publicado: (2020)

Sodium butyrate inhibits aerobic glycolysis of hepatocellular carcinoma cells via the c‐myc/hexokinase 2 pathway
por: Yu, Qiang, et al.
Publicado: (2022)

Aerobic glycolysis promotes tumor immune evasion and tumor cell stemness through the noncanonical function of hexokinase 2
por: He, Haiyan, et al.
Publicado: (2023)

lncRNA KCNQ1OT1 may function as a competitive endogenous RNA in atrial fibrillation by sponging miR-223-3p
por: Dai, Weiran, et al.
Publicado: (2021)

Long non-coding RNA KCNQ1OT1 up-regulates CTNND1 by sponging miR-329-3p to induce the proliferation, migration, invasion, and inhibit apoptosis of colorectal cancer cells
por: Liu, Xing, et al.
Publicado: (2020)

Long non‐coding RNA KCNQ1OT1 promotes the progression of gastric cancer via the miR‐145‐5p/ARF6 axis
por: Zhong, Xiongdong, et al.
Publicado: (2021)

KCNQ1OT1 accelerates gastric cancer progression via miR-4319/DRAM2 axis
por: Wang, Jijun, et al.
Publicado: (2020)

Upregulation and the clinical significance of KCNQ1OT1 and HAGLROS lncRNAs in papillary thyroid cancer: An observational study
por: Mutlu Icduygu, Fadime, et al.
Publicado: (2023)

Potassium ions promote hexokinase-II dependent glycolysis
por: Bischof, Helmut, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8u8lijdc1ksqv4s5qskjsrbmt9