CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD(+)/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats

Mitochondrial oxidative stress is a significant contributor to the pathogenesis of diabetic kidney disease (DKD). We previously showed that mitochondrial oxidative stress in the kidneys of Zucker diabetic fatty rats is associated with a decreased intracellular NAD(+)/NADH ratio and NAD(+)-dependent...

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Detalles Bibliográficos
Autores principales: Ogura, Yoshio, Kitada, Munehiro, Xu, Jing, Monno, Itaru, Koya, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343471/
https://www.ncbi.nlm.nih.gov/pubmed/32507768
http://dx.doi.org/10.18632/aging.103410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343471/
https://www.ncbi.nlm.nih.gov/pubmed/32507768
http://dx.doi.org/10.18632/aging.103410

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