miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity

To human osteoblasts dexamethasone (DEX) treatment induces significant oxidative injury and cytotoxicity. Inhibition of CAB39 (calcium binding protein 39)-targeting microRNA can induce CAB39 upregulation, activating AMP-activated protein kinase (AMPK) signaling and offering osteoblast cytoprotection...

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Detalles Bibliográficos
Autores principales: Zhuang, Yu, Wang, Shouguo, Fei, Haodong, Ji, Feng, Sun, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343481/
https://www.ncbi.nlm.nih.gov/pubmed/32527986
http://dx.doi.org/10.18632/aging.103341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343481/
https://www.ncbi.nlm.nih.gov/pubmed/32527986
http://dx.doi.org/10.18632/aging.103341

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