Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice

Autophagosome accumulation is observed in the distal axons of Alzheimer disease (AD) patients and AD animal models, suggesting that deficient retrograde transport and impaired autophagic clearance of beta-amyloid (A β) contribute to AD pathogenesis. Expression of the retrograde axonal transport-rela...

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Detalles Bibliográficos
Autores principales: Zhou, Fanlin, Xiong, Xiaomin, Li, Shijie, Liang, Jie, Zhang, Xiong, Tian, Mingyuan, Li, Xiaoju, Gao, Minna, Tang, Li, Li, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343509/
https://www.ncbi.nlm.nih.gov/pubmed/32584265
http://dx.doi.org/10.18632/aging.103382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343509/
https://www.ncbi.nlm.nih.gov/pubmed/32584265
http://dx.doi.org/10.18632/aging.103382

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