Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics

Mendelian randomization (MR) is a valuable tool for detecting causal effects using genetic variant associations. Opportunities to apply MR are growing rapidly with the number of genome-wide association studies (GWAS). However, existing MR methods rely on strong assumptions that are often violated, l...

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Detalles Bibliográficos
Autores principales: Morrison, Jean, Knoblauch, Nicholas, Marcus, Joseph H., Stephens, Matthew, He, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343608/
https://www.ncbi.nlm.nih.gov/pubmed/32451458
http://dx.doi.org/10.1038/s41588-020-0631-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343608/
https://www.ncbi.nlm.nih.gov/pubmed/32451458
http://dx.doi.org/10.1038/s41588-020-0631-4

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