Histone chaperone FACT is essential to overcome replication stress in mammalian cells

The histone chaperone FACT is upregulated during mammary tumorigenesis and necessary for the viability and growth of breast tumor cells. We established that only proliferating tumor cells are sensitive to FACT knockdown, suggesting that FACT functions during DNA replication in tumor cells but not in...

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Detalles Bibliográficos
Autores principales: Prendergast, Laura, Hong, Erin, Safina, Alfiya, Poe, Dante, Gurova, Katerina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343669/
https://www.ncbi.nlm.nih.gov/pubmed/32533099
http://dx.doi.org/10.1038/s41388-020-1346-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343669/
https://www.ncbi.nlm.nih.gov/pubmed/32533099
http://dx.doi.org/10.1038/s41388-020-1346-9

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