Therapy-Induced Changes in CXCR4 Expression in Tumor Xenografts Can Be Monitored Noninvasively with N-[(11)C]Methyl-AMD3465 PET

PURPOSE: Chemokine CXCL12 and its receptor CXCR4 are constitutively overexpressed in human cancers. The CXCL12-CXCR4 signaling axis plays an important role in tumor progression and metastasis, but also in treatment-induced recruitment of CXCR4-expressing cytotoxic immune cells. Here, we aimed to dem...

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Detalles Bibliográficos
Autores principales: Hartimath, SV, Draghiciu, O., Daemen, T, Nijman, H.W., van Waarde, A., Dierckx, R.A.J.O., de Vries, E.F.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343732/
https://www.ncbi.nlm.nih.gov/pubmed/31802362
http://dx.doi.org/10.1007/s11307-019-01447-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343732/
https://www.ncbi.nlm.nih.gov/pubmed/31802362
http://dx.doi.org/10.1007/s11307-019-01447-x

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