Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate

Regulatory B cells restrict immune and inflammatory responses across a number of contexts. This capacity is mediated primarily through the production of IL-10. Here we demonstrate that the induction of a regulatory program in human B cells is dependent on a metabolic priming event driven by choleste...

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Detalles Bibliográficos
Autores principales: Bibby, Jack A., Purvis, Harriet A., Hayday, Thomas, Chandra, Anita, Okkenhaug, Klaus, Rosenzweig, Sofia, Aksentijevich, Ivona, Wood, Michael, Lachmann, Helen J., Kemper, Claudia, Cope, Andrew P., Perucha, Esperanza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343868/
https://www.ncbi.nlm.nih.gov/pubmed/32641742
http://dx.doi.org/10.1038/s41467-020-17179-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343868/
https://www.ncbi.nlm.nih.gov/pubmed/32641742
http://dx.doi.org/10.1038/s41467-020-17179-4

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