Multi-Step Ubiquitin Decoding Mechanism for Proteasomal Degradation

The 26S proteasome is a 2.5-MDa protease complex responsible for the selective and ATP-dependent degradation of ubiquitylated proteins in eukaryotic cells. Proteasome-mediated protein degradation accounts for ~70% of all cellular proteolysis under basal conditions, and thereby any dysfunction can le...

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Detalles Bibliográficos
Autores principales: Tsuchiya, Hikaru, Endo, Akinori, Saeki, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344625/
https://www.ncbi.nlm.nih.gov/pubmed/32585960
http://dx.doi.org/10.3390/ph13060128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344625/
https://www.ncbi.nlm.nih.gov/pubmed/32585960
http://dx.doi.org/10.3390/ph13060128

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