Cargando…

Bone-Seeking Matrix Metalloproteinase Inhibitors for the Treatment of Skeletal Malignancy

Matrix metalloproteinases (MMPs) are a family of enzymes involved at different stages of cancer progression and metastasis. We previously identified a novel class of bisphosphonic inhibitors, selective for MMPs crucial for bone remodeling, such as MMP-2. Due to the increasing relevance of specific M...

Descripción completa

Detalles Bibliográficos
Autores principales:	Laghezza, Antonio, Piemontese, Luca, Brunetti, Leonardo, Caradonna, Alessia, Agamennone, Mariangela, Di Pizio, Antonella, Pochetti, Giorgio, Montanari, Roberta, Capelli, Davide, Tauro, Marilena, Loiodice, Fulvio, Tortorella, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344628/ https://www.ncbi.nlm.nih.gov/pubmed/32492898 http://dx.doi.org/10.3390/ph13060113

Ejemplares similares

(2-Aminobenzothiazole)-Methyl-1,1-Bisphosphonic Acids: Targeting Matrix Metalloproteinase 13 Inhibition to the Bone
por: Laghezza, Antonio, et al.
Publicado: (2021)

Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin
por: Montanari, Roberta, et al.
Publicado: (2016)

Dual targeting of cancer-related human matrix metalloproteinases and carbonic anhydrases by chiral N-(biarylsulfonyl)-phosphonic acids
por: Luisi, Grazia, et al.
Publicado: (2017)

Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode
por: Capelli, Davide, et al.
Publicado: (2016)

Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease
por: Brunetti, Leonardo, et al.
Publicado: (2019)

Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors
por: Brunetti, Leonardo, et al.
Publicado: (2020)

Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis
por: Brusotti, Gloria, et al.
Publicado: (2017)

Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases
por: Leuci, Rosalba, et al.
Publicado: (2020)

Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment
por: Shay, Gemma, et al.
Publicado: (2017)

A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE)
por: Leuci, Rosalba, et al.
Publicado: (2022)

Amino Acid Derivatives as New Zinc Binding Groups for the Design of Selective Matrix Metalloproteinase Inhibitors
por: Giustiniano, Mariateresa, et al.
Publicado: (2013)

Seeking for Non-Zinc-Binding MMP-2 Inhibitors: Synthesis, Biological Evaluation and Molecular Modelling Studies
por: Ammazzalorso, Alessandra, et al.
Publicado: (2016)

Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents
por: Poliseno, Viviana, et al.
Publicado: (2021)

Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease
por: Carocci, Alessia, et al.
Publicado: (2022)

Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition
por: Capelli, Davide, et al.
Publicado: (2023)

An Integrated Computational Approach to Rationalize the Activity of Non-Zinc-Binding MMP-2 Inhibitors
por: Di Pizio, Antonella, et al.
Publicado: (2012)

Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease
por: Piemontese, Luca, et al.
Publicado: (2018)

Cutting to the Chase: How Matrix Metalloproteinase-2 Activity Controls Breast-Cancer-to-Bone Metastasis
por: Tauro, Marilena, et al.
Publicado: (2018)

Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Inflammation and Fibrosis of Skeletal Muscles
por: Alameddine, Hala S., et al.
Publicado: (2016)

Food Industry Byproducts as Starting Material for Innovative, Green Feed Formulation: A Sustainable Alternative for Poultry Feeding
por: Brunetti, Leonardo, et al.
Publicado: (2022)

Elucidation of the potential roles of matrix metalloproteinases in skeletal biology
por: Krane, Stephen M
Publicado: (2003)

Microvesicles shed from fibroblasts act as metalloproteinase carriers in a 3-D collagen matrix
por: Laghezza Masci, Valentina, et al.
Publicado: (2016)

Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies
por: Ammazzalorso, Alessandra, et al.
Publicado: (2020)

Insights into the Complex Formed by Matrix Metalloproteinase-2 and Alloxan Inhibitors: Molecular Dynamics Simulations and Free Energy Calculations
por: Giangreco, Ilenia, et al.
Publicado: (2011)

Rule out of acute aortic dissection with plasma matrix metalloproteinase 8 in the emergency department
por: Giachino, Francesca, et al.
Publicado: (2013)

Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists
por: Sabatino, Lina, et al.
Publicado: (2019)

Broad-Spectrum Activity of Small Molecules Acting against Influenza a Virus: Biological and Computational Studies
por: Agamennone, Mariangela, et al.
Publicado: (2022)

Different roles of matrix metalloproteinase 2 in osteolysis of skeletal dysplasia and bone metastasis
por: Li, Xiumao, et al.
Publicado: (2021)

Liquid and Vapor Phase of Four Conifer-Derived Essential Oils: Comparison of Chemical Compositions and Antimicrobial and Antioxidant Properties
por: Garzoli, Stefania, et al.
Publicado: (2021)

Role of Matrix Metalloproteinase 13 in Both Endochondral and Intramembranous Ossification during Skeletal Regeneration
por: Behonick, Danielle J., et al.
Publicado: (2007)

Effects of Resistance Training on Matrix Metalloproteinase Activity in Skeletal Muscles and Blood Circulation During Aging
por: de Sousa Neto, Ivo V., et al.
Publicado: (2018)

Discovery of Novel Chemical Series of OXA-48 β-Lactamase Inhibitors by High-Throughput Screening
por: Garofalo, Barbara, et al.
Publicado: (2021)

Functional relationship between matrix metalloproteinase-11 and matrix metalloproteinase-14
por: Buache, Emilie, et al.
Publicado: (2014)

Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in the hair cycle
por: HOU, CHUN, et al.
Publicado: (2016)

Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARγ Agonists and their Antidiabetic Effects on Type 2 Diabetes
por: Yasmin, Sabina, et al.
Publicado: (2017)

Matrix metalloproteinases and epileptogenesis
por: Ikonomidou, Chrysanthy
Publicado: (2014)

Matrix Metalloproteinases and Glaucoma
por: Kim, Moo Hyun, et al.
Publicado: (2022)

Hampering the early aggregation of PrP-E200K protein by charge-based inhibitors: a computational study
por: Agamennone, Mariangela, et al.
Publicado: (2021)

Activation and localization of matrix metalloproteinase-2 and -9 in the skeletal muscle of the muscular dystrophy dog (CXMD(J))
por: Fukushima, Kazuhiro, et al.
Publicado: (2007)

Expression of matrix metalloproteinase-11 is increased under conditions of insulin resistance
por: Arcidiacono, Biagio, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tf8hn1c89m4e5u6k2smgt49k9o