Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells

Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades hemoglobin in intact blood or in isolated erythrocy...

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Autores principales: Lehene, Maria, Fischer-Fodor, Eva, Scurtu, Florina, Hădade, Niculina D., Gal, Emese, Mot, Augustin C., Matei, Alina, Silaghi-Dumitrescu, Radu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344896/
https://www.ncbi.nlm.nih.gov/pubmed/32471171
http://dx.doi.org/10.3390/ph13060107
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author Lehene, Maria
Fischer-Fodor, Eva
Scurtu, Florina
Hădade, Niculina D.
Gal, Emese
Mot, Augustin C.
Matei, Alina
Silaghi-Dumitrescu, Radu
author_facet Lehene, Maria
Fischer-Fodor, Eva
Scurtu, Florina
Hădade, Niculina D.
Gal, Emese
Mot, Augustin C.
Matei, Alina
Silaghi-Dumitrescu, Radu
author_sort Lehene, Maria
collection PubMed
description Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades hemoglobin in intact blood or in isolated erythrocytes. The survival rates and metabolic activities of several leukocyte subsets implicated in the antiviral cellular immune response are also affected. Excess ascorbate is thus an unselective biological stress agent.
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spelling pubmed-73448962020-07-09 Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells Lehene, Maria Fischer-Fodor, Eva Scurtu, Florina Hădade, Niculina D. Gal, Emese Mot, Augustin C. Matei, Alina Silaghi-Dumitrescu, Radu Pharmaceuticals (Basel) Article Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades hemoglobin in intact blood or in isolated erythrocytes. The survival rates and metabolic activities of several leukocyte subsets implicated in the antiviral cellular immune response are also affected. Excess ascorbate is thus an unselective biological stress agent. MDPI 2020-05-27 /pmc/articles/PMC7344896/ /pubmed/32471171 http://dx.doi.org/10.3390/ph13060107 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lehene, Maria
Fischer-Fodor, Eva
Scurtu, Florina
Hădade, Niculina D.
Gal, Emese
Mot, Augustin C.
Matei, Alina
Silaghi-Dumitrescu, Radu
Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells
title Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells
title_full Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells
title_fullStr Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells
title_full_unstemmed Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells
title_short Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells
title_sort excess ascorbate is a chemical stress agent against proteins and cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344896/
https://www.ncbi.nlm.nih.gov/pubmed/32471171
http://dx.doi.org/10.3390/ph13060107
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