Exploration and Modulation of Antibody Fragment Biophysical Properties by Replacing the Framework Region Sequences

In order to increase the successful development of recombinant antibodies and fragments, it seems fundamental to enhance their expression and/or biophysical properties, such as the thermal, chemical, and pH stabilities. In this study, we employed a method bases on replacing the antibody framework re...

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Detalles Bibliográficos
Autores principales: Cnudde, Thomas, Lakhrif, Zineb, Bourgoin, Justine, Boursin, Fanny, Horiot, Catherine, Henriquet, Corinne, di Tommaso, Anne, Juste, Matthieu Olivier, Jiacomini, Isabella Gizzi, Dimier-Poisson, Isabelle, Pugnière, Martine, Mévélec, Marie-Nöelle, Aubrey, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344962/
https://www.ncbi.nlm.nih.gov/pubmed/32326443
http://dx.doi.org/10.3390/antib9020009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344962/
https://www.ncbi.nlm.nih.gov/pubmed/32326443
http://dx.doi.org/10.3390/antib9020009

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