Cargando…

Transcriptome-Wide Analysis of CXCR5 Deficient Retinal Pigment Epithelial (RPE) Cells Reveals Molecular Signatures of RPE Homeostasis

Age-related macular degeneration (AMD) is the most common cause of irreversible blindness in the elderly population. In our previous studies, we found that deficiency of CXCR5 causes AMD-like pathological phenotypes in mice, characterized by abnormalities and dysfunction of the retinal pigment epith...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saddala, Madhu Sudhana, Lennikov, Anton, Mukwaya, Anthony, Huang, Hu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345337/ https://www.ncbi.nlm.nih.gov/pubmed/32492870 http://dx.doi.org/10.3390/biomedicines8060147

Ejemplares similares

Autoimmune-Mediated Retinopathy in CXCR5-Deficient Mice as the Result of Age-Related Macular Degeneration Associated Proteins Accumulation
por: Lennikov, Anton, et al.
Publicado: (2019)

RNA-seq data from C-X-C chemokine receptor type 5 (CXCR5) gene knockout aged mice with retinal degeneration phenotype
por: Saddala, Madhu Sudhana, et al.
Publicado: (2020)

Transcriptome-wide analysis of differentially expressed chemokine receptors, SNPs, and SSRs in the age-related macular degeneration
por: Saddala, Madhu Sudhana, et al.
Publicado: (2019)

RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio
por: Saddala, Madhu Sudhana, et al.
Publicado: (2020)

Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors
por: Brown, Emily E., et al.
Publicado: (2019)

Discovery of Small-Molecule Activators for Glucose-6-Phosphate Dehydrogenase (G6PD) Using Machine Learning Approaches
por: Saddala, Madhu Sudhana, et al.
Publicado: (2020)

Selective Ablation of Dehydrodolichyl Diphosphate Synthase in Murine Retinal Pigment Epithelium (RPE) Causes RPE Atrophy and Retinal Degeneration
por: DeRamus, Marci L., et al.
Publicado: (2020)

Age-Related Changes in the Retinal Pigment Epithelium (RPE)
por: Gu, Xiaorong, et al.
Publicado: (2012)

Proteomics of Human Retinal Pigment Epithelium (RPE) Cells
por: Beranova-Giorgianni, Sarka, et al.
Publicado: (2018)

Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions
por: Bhattarai, Niina, et al.
Publicado: (2022)

Discovery of novel L-type voltage-gated calcium channel blockers and application for the prevention of inflammation and angiogenesis
por: Saddala, Madhu Sudhana, et al.
Publicado: (2020)

Evaluation for Retinal Therapy for RPE65 Variation Assessed in hiPSC Retinal Pigment Epithelial Cells
por: Nash, Benjamin M., et al.
Publicado: (2021)

Cadherins in the retinal pigment epithelium (RPE) revisited: P-cadherin is the highly dominant cadherin expressed in human and mouse RPE in vivo
por: Yang, Xue, et al.
Publicado: (2018)

Ex-vivo models of the Retinal Pigment Epithelium (RPE) in long-term culture faithfully recapitulate key structural and physiological features of native RPE
por: Lynn, Savannah A., et al.
Publicado: (2017)

Mechanism of Nucleic Acid Sensing in Retinal Pigment Epithelium (RPE): RIG-I Mediates Type I Interferon Response in Human RPE
por: Schustak, Joshua, et al.
Publicado: (2021)

A Method for the Isolation and Culture of Adult Rat Retinal Pigment Epithelial (RPE) Cells to Study Retinal Diseases
por: Heller, Janosch P., et al.
Publicado: (2015)

Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells
por: Bhattarai, Niina, et al.
Publicado: (2021)

TNFα induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier function
por: Twarog, Michael, et al.
Publicado: (2023)

DJ-1-Dependent Regulation of Oxidative Stress in the Retinal Pigment Epithelium (RPE)
por: Shadrach, Karen G., et al.
Publicado: (2013)

Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level
por: Udry, Florian, et al.
Publicado: (2020)

Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual Function
por: Rohrer, Bärbel, et al.
Publicado: (2021)

Correction: DJ-1-Dependent Regulation of Oxidative Stress in the Retinal Pigment Epithelium (RPE)
Publicado: (2014)

Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)
por: Giannaccini, Martina, et al.
Publicado: (2014)

Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases
por: Keeling, Eloise, et al.
Publicado: (2018)

Correction: DJ-1-Dependent Regulation of Oxidative Stress in the Retinal Pigment Epithelium (RPE)
por: Shadrach, Karen G., et al.
Publicado: (2017)

Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1
por: Upadhyay, Mala, et al.
Publicado: (2020)

A Comprehensive Study of the Retinal Phenotype of Rpe65-Deficient Dogs
por: Annear, Matthew J, et al.
Publicado: (2021)

Nanoscopic Approach to Study the Early Stages of Epithelial to Mesenchymal Transition (EMT) of Human Retinal Pigment Epithelial (RPE) Cells In Vitro
por: Chtcheglova, Lilia A., et al.
Publicado: (2020)

Retinal Structure in RPE65-Associated Retinal Dystrophy
por: Kumaran, Neruban, et al.
Publicado: (2020)

Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela
por: Grigoryan, Eleonora N., et al.
Publicado: (2016)

Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells
por: Efstathiou, Nikolaos E., et al.
Publicado: (2020)

Dynamic human retinal pigment epithelium (RPE) and choroid architecture based on single-cell transcriptomic landscape analysis
por: Huang, Lulin, et al.
Publicado: (2022)

Proteomics reveals ablation of PlGF increases antioxidant and neuroprotective proteins in the diabetic mouse retina
por: Saddala, Madhu Sudhana, et al.
Publicado: (2018)

Riboflavin deficiency leads to irreversible cellular changes in the RPE and disrupts retinal function through alterations in cellular metabolic homeostasis
por: Sinha, Tirthankar, et al.
Publicado: (2022)

Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells (MA09-hRPE) in macular degeneration
por: Qiu, Tina Guanting
Publicado: (2019)

Expression profiling of the RPE in zebrafish smarca4 mutant revealed altered signals that potentially affect RPE and retinal differentiation
por: Zhang, Liyun, et al.
Publicado: (2014)

Complement Factor H Loss in RPE Cells Causes Retinal Degeneration in a Human RPE-Porcine Retinal Explant Co-Culture Model
por: Armento, Angela, et al.
Publicado: (2021)

Human Ribosomal Proteins RPeL27, RPeL43, and RPeL41 Are Upregulated in Nasopharyngeal Carcinoma Cell Lines
por: Sim, Edmund Ui-Hang, et al.
Publicado: (2016)

Chloride Intracellular Channel 4 Is Critical for the Epithelial Morphogenesis of RPE Cells and Retinal Attachment
por: Chuang, Jen-Zen, et al.
Publicado: (2010)

Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7
por: Zhang, Youwen, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_kjcud1nbm6c6r4nndddgkq5io3