Potential Anti-Tumor Drug: Co-Crystal 5-Fluorouracil-nicotinamide

[Image: see text] 5-Fluorouracil-nicotinamide (5-FU-NCM), a co-crystal with a 2D layer structure formed by hydrogen bonds, was synthesized by solvent evaporation and liquid phase-assisted grinding at room temperature. Compared to 5-FU alone, the results of solubility, oil–water partition coefficient...

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Autores principales: Zhang, Zhuyan, Yu, Nan, Xue, Chang, Gao, Shan, Deng, Zhaopeng, Li, Min, Liu, Cong, Castellot, John, Han, Siying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345411/
https://www.ncbi.nlm.nih.gov/pubmed/32656396
http://dx.doi.org/10.1021/acsomega.9b03574
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author Zhang, Zhuyan
Yu, Nan
Xue, Chang
Gao, Shan
Deng, Zhaopeng
Li, Min
Liu, Cong
Castellot, John
Han, Siying
author_facet Zhang, Zhuyan
Yu, Nan
Xue, Chang
Gao, Shan
Deng, Zhaopeng
Li, Min
Liu, Cong
Castellot, John
Han, Siying
author_sort Zhang, Zhuyan
collection PubMed
description [Image: see text] 5-Fluorouracil-nicotinamide (5-FU-NCM), a co-crystal with a 2D layer structure formed by hydrogen bonds, was synthesized by solvent evaporation and liquid phase-assisted grinding at room temperature. Compared to 5-FU alone, the results of solubility, oil–water partition coefficient, anti-tumor effect in vivo and vitro, acute toxicity, and pharmacokinetic parameters indicate that the co-crystal is a potential anti-tumor drug.
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spelling pubmed-73454112020-07-10 Potential Anti-Tumor Drug: Co-Crystal 5-Fluorouracil-nicotinamide Zhang, Zhuyan Yu, Nan Xue, Chang Gao, Shan Deng, Zhaopeng Li, Min Liu, Cong Castellot, John Han, Siying ACS Omega [Image: see text] 5-Fluorouracil-nicotinamide (5-FU-NCM), a co-crystal with a 2D layer structure formed by hydrogen bonds, was synthesized by solvent evaporation and liquid phase-assisted grinding at room temperature. Compared to 5-FU alone, the results of solubility, oil–water partition coefficient, anti-tumor effect in vivo and vitro, acute toxicity, and pharmacokinetic parameters indicate that the co-crystal is a potential anti-tumor drug. American Chemical Society 2020-06-24 /pmc/articles/PMC7345411/ /pubmed/32656396 http://dx.doi.org/10.1021/acsomega.9b03574 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Zhang, Zhuyan
Yu, Nan
Xue, Chang
Gao, Shan
Deng, Zhaopeng
Li, Min
Liu, Cong
Castellot, John
Han, Siying
Potential Anti-Tumor Drug: Co-Crystal 5-Fluorouracil-nicotinamide
title Potential Anti-Tumor Drug: Co-Crystal 5-Fluorouracil-nicotinamide
title_full Potential Anti-Tumor Drug: Co-Crystal 5-Fluorouracil-nicotinamide
title_fullStr Potential Anti-Tumor Drug: Co-Crystal 5-Fluorouracil-nicotinamide
title_full_unstemmed Potential Anti-Tumor Drug: Co-Crystal 5-Fluorouracil-nicotinamide
title_short Potential Anti-Tumor Drug: Co-Crystal 5-Fluorouracil-nicotinamide
title_sort potential anti-tumor drug: co-crystal 5-fluorouracil-nicotinamide
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345411/
https://www.ncbi.nlm.nih.gov/pubmed/32656396
http://dx.doi.org/10.1021/acsomega.9b03574
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