Ion Binding Properties of a Naturally Occurring Metalloantibody

LT1009 is a humanized version of murine LT1002 IgG1 that employs two bridging Ca(2+) ions to bind its antigen, the biologically active lipid sphingosine-1-phosphate (S1P). We crystallized and determined the X-ray crystal structure of the LT1009 Fab fragment in 10 mM CaCl(2) and found that it binds t...

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Detalles Bibliográficos
Autores principales: Farokhi, Elinaz, Fleming, Jonathan K., Erasmus, M. Frank, Ward, Aaron D., Wu, Yunjin, Gutierrez, Maria G., Wojciak, Jonathan M., Huxford, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345679/
https://www.ncbi.nlm.nih.gov/pubmed/32316193
http://dx.doi.org/10.3390/antib9020010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345679/
https://www.ncbi.nlm.nih.gov/pubmed/32316193
http://dx.doi.org/10.3390/antib9020010

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