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Ion Binding Properties of a Naturally Occurring Metalloantibody

LT1009 is a humanized version of murine LT1002 IgG1 that employs two bridging Ca(2+) ions to bind its antigen, the biologically active lipid sphingosine-1-phosphate (S1P). We crystallized and determined the X-ray crystal structure of the LT1009 Fab fragment in 10 mM CaCl(2) and found that it binds t...

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Detalles Bibliográficos
Autores principales:	Farokhi, Elinaz, Fleming, Jonathan K., Erasmus, M. Frank, Ward, Aaron D., Wu, Yunjin, Gutierrez, Maria G., Wojciak, Jonathan M., Huxford, Tom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345679/ https://www.ncbi.nlm.nih.gov/pubmed/32316193 http://dx.doi.org/10.3390/antib9020010

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