Baicalein Inhibits Benzo[a]pyrene-Induced Toxic Response by Downregulating Src Phosphorylation and by Upregulating NRF2-HMOX1 System

Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP. The BaP-AHR-CYP1A1 axis generates...

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Detalles Bibliográficos
Autores principales: Tanaka, Yuka, Ito, Takamichi, Tsuji, Gaku, Furue, Masutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346154/
https://www.ncbi.nlm.nih.gov/pubmed/32526964
http://dx.doi.org/10.3390/antiox9060507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346154/
https://www.ncbi.nlm.nih.gov/pubmed/32526964
http://dx.doi.org/10.3390/antiox9060507

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