Protoflavone-Chalcone Hybrids Exhibit Enhanced Antitumor Action through Modulating Redox Balance, Depolarizing the Mitochondrial Membrane, and Inhibiting ATR-Dependent Signaling

Hybrid compounds combine fragments with complementary targets to achieve a common pharmacological goal. This approach represents an increasingly popular strategy for drug discovery. In this work, we aimed to design antitumor hybrid compounds based on an inhibitor of ataxia-telangiectasia and Rad3-re...

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Detalles Bibliográficos
Autores principales: Latif, Ahmed Dhahir, Jernei, Tamás, Podolski-Renić, Ana, Kuo, Ching-Ying, Vágvölgyi, Máté, Girst, Gábor, Zupkó, István, Develi, Sedef, Ulukaya, Engin, Wang, Hui-Chun, Pešić, Milica, Csámpai, Antal, Hunyadi, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346169/
https://www.ncbi.nlm.nih.gov/pubmed/32545536
http://dx.doi.org/10.3390/antiox9060519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346169/
https://www.ncbi.nlm.nih.gov/pubmed/32545536
http://dx.doi.org/10.3390/antiox9060519

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