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Iminosugar idoBR1 Isolated from Cucumber Cucumis sativus Reduces Inflammatory Activity
[Image: see text] Cucumbers have been anecdotally claimed to have anti-inflammatory activity for a long time, but the active principle was not identified. idoBR1, (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid, is an iminosugar amino acid isolated from fruits of certain cucumbers, Cucumi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346245/ https://www.ncbi.nlm.nih.gov/pubmed/32656449 http://dx.doi.org/10.1021/acsomega.0c02092 |
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author | Nash, Robert J. Bartholomew, Barbara Penkova, Yana B. Rotondo, Dino Yamasaka, Fernanda Stafford, Graham P. Jenkinson, Sarah F. Fleet, George W. J. |
author_facet | Nash, Robert J. Bartholomew, Barbara Penkova, Yana B. Rotondo, Dino Yamasaka, Fernanda Stafford, Graham P. Jenkinson, Sarah F. Fleet, George W. J. |
author_sort | Nash, Robert J. |
collection | PubMed |
description | [Image: see text] Cucumbers have been anecdotally claimed to have anti-inflammatory activity for a long time, but the active principle was not identified. idoBR1, (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid, is an iminosugar amino acid isolated from fruits of certain cucumbers, Cucumis sativus (Cucurbitaceae). It has no chromophore and analytically behaves like an amino acid making detection and identification difficult. It has anti-inflammatory activity reducing lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α) in THP-1 cells and ex vivo human blood. It showed selective inhibition of human α-l-iduronidase and sialidases from both bacteria (Tannerella forsythia) and human THP-1 cells. idoBR1 and cucumber extract reduced the binding of hyaluronic acid (HA) to CD44 in LPS-stimulated THP-1 cells and may function as an anti-inflammatory agent by inhibiting induced sialidase involved in the production of functionally active HA adhesive CD44. Similar to the related iminosugars, idoBR1 is excreted unchanged in urine following consumption. Its importance in the diet should be further evaluated. |
format | Online Article Text |
id | pubmed-7346245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-73462452020-07-10 Iminosugar idoBR1 Isolated from Cucumber Cucumis sativus Reduces Inflammatory Activity Nash, Robert J. Bartholomew, Barbara Penkova, Yana B. Rotondo, Dino Yamasaka, Fernanda Stafford, Graham P. Jenkinson, Sarah F. Fleet, George W. J. ACS Omega [Image: see text] Cucumbers have been anecdotally claimed to have anti-inflammatory activity for a long time, but the active principle was not identified. idoBR1, (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid, is an iminosugar amino acid isolated from fruits of certain cucumbers, Cucumis sativus (Cucurbitaceae). It has no chromophore and analytically behaves like an amino acid making detection and identification difficult. It has anti-inflammatory activity reducing lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α) in THP-1 cells and ex vivo human blood. It showed selective inhibition of human α-l-iduronidase and sialidases from both bacteria (Tannerella forsythia) and human THP-1 cells. idoBR1 and cucumber extract reduced the binding of hyaluronic acid (HA) to CD44 in LPS-stimulated THP-1 cells and may function as an anti-inflammatory agent by inhibiting induced sialidase involved in the production of functionally active HA adhesive CD44. Similar to the related iminosugars, idoBR1 is excreted unchanged in urine following consumption. Its importance in the diet should be further evaluated. American Chemical Society 2020-06-23 /pmc/articles/PMC7346245/ /pubmed/32656449 http://dx.doi.org/10.1021/acsomega.0c02092 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Nash, Robert J. Bartholomew, Barbara Penkova, Yana B. Rotondo, Dino Yamasaka, Fernanda Stafford, Graham P. Jenkinson, Sarah F. Fleet, George W. J. Iminosugar idoBR1 Isolated from Cucumber Cucumis sativus Reduces Inflammatory Activity |
title | Iminosugar idoBR1 Isolated from Cucumber Cucumis sativus Reduces Inflammatory Activity |
title_full | Iminosugar idoBR1 Isolated from Cucumber Cucumis sativus Reduces Inflammatory Activity |
title_fullStr | Iminosugar idoBR1 Isolated from Cucumber Cucumis sativus Reduces Inflammatory Activity |
title_full_unstemmed | Iminosugar idoBR1 Isolated from Cucumber Cucumis sativus Reduces Inflammatory Activity |
title_short | Iminosugar idoBR1 Isolated from Cucumber Cucumis sativus Reduces Inflammatory Activity |
title_sort | iminosugar idobr1 isolated from cucumber cucumis sativus reduces inflammatory activity |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346245/ https://www.ncbi.nlm.nih.gov/pubmed/32656449 http://dx.doi.org/10.1021/acsomega.0c02092 |
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