Cargando…
Heptameric Peptide Interferes with Amyloid-β Aggregation by Structural Reorganization of the Toxic Oligomers
[Image: see text] Pathogenesis of Alzheimer’s disease (AD), the most common type of dementia, involves misfolding and aggregation of the extracellular amyloid-β (Aβ) protein where the intermediate oligomers, formed during the aggregation progression cascade, are considered the prime toxic species. H...
Autores principales: | Bhattacharyya, Rajanya, Bhattacharjee, Sayan, Pathak, Bani K., Sengupta, Jayati |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2020
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346273/ https://www.ncbi.nlm.nih.gov/pubmed/32656435 http://dx.doi.org/10.1021/acsomega.0c01730 |
Ejemplares similares
-
The Role of α-sheet in Amyloid Oligomer Aggregation and Toxicity
por: Bi, Timothy M., et al.
Publicado: (2018) -
The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy
por: Sengupta, Urmi, et al.
Publicado: (2016) -
Transthyretin Inhibits Primary and Secondary Nucleations
of Amyloid-β Peptide Aggregation and Reduces the Toxicity
of Its Oligomers
por: Ghadami, Seyyed Abolghasem, et al.
Publicado: (2020) -
Distinct thermodynamic signature of oligomer generation in the aggregation of the amyloid-β peptide
por: Cohen, Samuel I. A., et al.
Publicado: (2018) -
The Toxicity of Amyloid β Oligomers
por: Zhao, Li Na, et al.
Publicado: (2012)