Proteomics reveals a therapeutic vulnerability via the combined blockade of APE1 and autophagy in lung cancer A549 cells

BACKGROUND: Drug resistance is a major cause of therapeutic failure that is often associated with elevated autophagy and apurinic/apyrimidinic endonuclease 1 (APE1) expression. Herein, we investigated the role of APE1 and autophagy in A549 cells treated with cisplatin. METHODS: SILAC proteomics was...

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Detalles Bibliográficos
Autores principales: Pan, Shu-Ting, Zhou, Ji, Yang, Fang, Zhou, Shu-Feng, Ren, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346405/
https://www.ncbi.nlm.nih.gov/pubmed/32641008
http://dx.doi.org/10.1186/s12885-020-07111-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346405/
https://www.ncbi.nlm.nih.gov/pubmed/32641008
http://dx.doi.org/10.1186/s12885-020-07111-w

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