Genome editing of CCR5 by AsCpf1 renders CD4(+)T cells resistance to HIV-1 infection

BACKGROUND: The chemokine receptor CCR5 is one of the co-receptor of HIV-1 infection. People with homozygous CCR5Δ32 deletion resist HIV-1 infection, which makes the CCR5 an important target for HIV-1 gene therapy. Although the CRISPR/Cas9 has ever been used for HIV-1 study, the newly developed CRIS...

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Detalles Bibliográficos
Autores principales: Liu, Zhepeng, Liang, Jin, Chen, Shuliang, Wang, Kewu, Liu, Xianhao, Liu, Beibei, Xia, Yang, Guo, Mingxiong, Zhang, Xiaoshi, Sun, Guihong, Tian, Geng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346486/
https://www.ncbi.nlm.nih.gov/pubmed/32670545
http://dx.doi.org/10.1186/s13578-020-00444-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346486/
https://www.ncbi.nlm.nih.gov/pubmed/32670545
http://dx.doi.org/10.1186/s13578-020-00444-w

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