Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritis

BACKGROUND: Celastrol has been proven effective in anti-inflammatory but was limited in the clinic due to the poor solubility and side effects induced by low bioavailability. Osteoarthritis has acidic and inflammatory environment. Our aim was to load celastrol into HMSNs and capped with chitosan to...

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Detalles Bibliográficos
Autores principales: Jin, Tian, Wu, Di, Liu, Xiao-Ming, Xu, Jiang-Tao, Ma, Bing-Jie, Ji, Yun, Jin, Yu-Ying, Wu, Si-Yin, Wu, Tao, Ma, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346635/
https://www.ncbi.nlm.nih.gov/pubmed/32641147
http://dx.doi.org/10.1186/s12951-020-00651-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346635/
https://www.ncbi.nlm.nih.gov/pubmed/32641147
http://dx.doi.org/10.1186/s12951-020-00651-0

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