Cargando…
Asymmetric Rab activation of vacuolar HOPS to catalyze SNARE complex assembly
Intracellular membrane fusion requires Rab-family GTPases, their effector tethers, soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins, and SNARE chaperones of the Sec1/Munc18 (SM), Sec17/α-SNAP, and Sec18/NSF families. We have developed an assay using fluorescence...
Autores principales: | Torng, Thomas, Song, Hongki, Wickner, William |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346727/ https://www.ncbi.nlm.nih.gov/pubmed/32160129 http://dx.doi.org/10.1091/mbc.E20-01-0019 |
Ejemplares similares
-
HOPS catalyzes the interdependent assembly of each vacuolar SNARE into a SNARE complex
por: Orr, Amy, et al.
Publicado: (2017) -
A short region upstream of the yeast vacuolar Qa-SNARE heptad-repeats promotes membrane fusion through enhanced SNARE complex assembly
por: Song, Hongki, et al.
Publicado: (2017) -
The tethering complex HOPS catalyzes assembly of the soluble SNARE Vam7 into fusogenic trans-SNARE complexes
por: Zick, Michael, et al.
Publicado: (2013) -
Phosphatidylinositol and phosphatidylinositol-3-phosphate activate HOPS to catalyze SNARE assembly, allowing small headgroup lipids to support the terminal steps of membrane fusion
por: Torng, Thomas, et al.
Publicado: (2021) -
HOPS recognizes each SNARE, assembling ternary trans-complexes for rapid fusion upon engagement with the 4th SNARE
por: Song, Hongki, et al.
Publicado: (2020)