Glibenclamide and HMR1098 normalize Cantú syndrome‐associated gain‐of‐function currents

Cantú syndrome (CS) is caused by dominant gain‐of‐function mutation in ATP‐dependent potassium channels. Cellular ATP concentrations regulate potassium current thereby coupling energy status with membrane excitability. No specific pharmacotherapeutic options are available to treat CS but I(KATP) cha...

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Detalles Bibliográficos
Autores principales: Houtman, Marien J. C., Chen, Xingyu, Qile, Muge, Duran, Karen, van Haaften, Gijs, Stary‐Weinzinger, Anna, van der Heyden, Marcel A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346732/
https://www.ncbi.nlm.nih.gov/pubmed/31119887
http://dx.doi.org/10.1111/jcmm.14329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346732/
https://www.ncbi.nlm.nih.gov/pubmed/31119887
http://dx.doi.org/10.1111/jcmm.14329

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