Clonality in haematopoietic stem cell ageing

Clonal haematopoiesis of indeterminate potential (CHIP) is widespread in the elderly. CHIP is driven by somatic mutations in leukaemia driver genes, such as Janus Kinase 2 (JAK2), Tet methylcytosine dioxygenase 2 (TET2), ASXL Transcriptional Regulator 1 (ASXL1) and DNA (cytosine-5)-methyltransferase...

Descripción completa

Detalles Bibliográficos
Autores principales: Terradas-Terradas, Maria, Robertson, Neil A., Chandra, Tamir, Kirschner, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ireland 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347006/
https://www.ncbi.nlm.nih.gov/pubmed/32526214
http://dx.doi.org/10.1016/j.mad.2020.111279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347006/
https://www.ncbi.nlm.nih.gov/pubmed/32526214
http://dx.doi.org/10.1016/j.mad.2020.111279

Ejemplares similares