MECHANISMS GENERATING CANCER GENOME COMPLEXITY FROM A SINGLE CELL DIVISION ERROR

The chromosome breakage-fusion-bridge (BFB) cycle is a mutational process that produces gene amplification and genome instability. Signatures of BFB cycles can be observed in cancer genomes alongside chromothripsis, another catastrophic mutational phenomenon. Here, we explain this association by elu...

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Detalles Bibliográficos
Autores principales: Umbreit, Neil T., Zhang, Cheng-Zhong, Lynch, Luke D., Blaine, Logan J., Cheng, Anna M., Tourdot, Richard, Sun, Lili, Almubarak, Hannah F., Judge, Kim, Mitchell, Thomas J., Spektor, Alexander, Pellman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347108/
https://www.ncbi.nlm.nih.gov/pubmed/32299917
http://dx.doi.org/10.1126/science.aba0712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347108/
https://www.ncbi.nlm.nih.gov/pubmed/32299917
http://dx.doi.org/10.1126/science.aba0712

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