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Somatic hypermutation analysis for improved identification of B cell clonal families from next-generation sequencing data
Adaptive immune receptor repertoire sequencing (AIRR-Seq) offers the possibility of identifying and tracking B cell clonal expansions during adaptive immune responses. Members of a B cell clone are descended from a common ancestor and share the same initial V(D)J rearrangement, but their B cell rece...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347241/ https://www.ncbi.nlm.nih.gov/pubmed/32574157 http://dx.doi.org/10.1371/journal.pcbi.1007977 |