Local frustration determines loop opening during the catalytic cycle of an oxidoreductase

Local structural frustration, the existence of mutually exclusive competing interactions, may explain why some proteins are dynamic while others are rigid. Frustration is thought to underpin biomolecular recognition and the flexibility of protein-binding sites. Here, we show how a small chemical mod...

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Detalles Bibliográficos
Autores principales: Stelzl, Lukas S, Mavridou, Despoina AI, Saridakis, Emmanuel, Gonzalez, Diego, Baldwin, Andrew J, Ferguson, Stuart J, Sansom, Mark SP, Redfield, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347389/
https://www.ncbi.nlm.nih.gov/pubmed/32568066
http://dx.doi.org/10.7554/eLife.54661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347389/
https://www.ncbi.nlm.nih.gov/pubmed/32568066
http://dx.doi.org/10.7554/eLife.54661

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