Cargando…
Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet
OBJECTIVE: Food intake normally stimulates release of satiety and insulin-stimulating intestinal hormones, such as glucagon-like peptide (GLP)-1. This response is blunted in obese insulin resistant subjects, but is rapidly restored following Roux-en-Y gastric bypass (RYGB) surgery. We hypothesised t...
Autores principales: | Wallenius, Ville, Elias, Erik, Elebring, Erik, Haisma, Bauke, Casselbrant, Anna, Larraufie, Pierre, Spak, Emma, Reimann, Frank, le Roux, Carel W, Docherty, Neil G, Gribble, Fiona M, Fändriks, Lars |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347417/ https://www.ncbi.nlm.nih.gov/pubmed/31753852 http://dx.doi.org/10.1136/gutjnl-2019-319372 |
Ejemplares similares
-
A Fatty Diet Induces a Jejunal Ketogenesis Which Inhibits Local SGLT1-Based Glucose Transport via an Acetylation Mechanism—Results from a Randomized Cross-Over Study between Iso-Caloric High-Fat versus High-Carbohydrate Diets in Healthy Volunteers
por: Elebring, Erik, et al.
Publicado: (2022) -
Glycemic Control and Metabolic Adaptation in Response to High-Fat versus High-Carbohydrate Diets—Data from a Randomized Cross-Over Study in Healthy Subjects
por: Wallenius, Ville, et al.
Publicado: (2021) -
Morphological Adaptation in the Jejunal Mucosa after Iso-Caloric High-Fat versus High-Carbohydrate Diets in Healthy Volunteers: Data from a Randomized Crossover Study
por: Casselbrant, Anna, et al.
Publicado: (2022) -
Glycocholic acid and butyrate synergistically increase vitamin D-induced calcium uptake in Caco-2 intestinal epithelial cell monolayers
por: Casselbrant, Anna, et al.
Publicado: (2020) -
SCFAs strongly stimulate PYY production in human enteroendocrine cells
por: Larraufie, P., et al.
Publicado: (2018)