Optimized ex vivo stimulation identifies multi-functional HBV-specific T cells in a majority of chronic hepatitis B patients

High antigen burden during chronic hepatitis B (CHB) results in a low frequency HBV-specific T cell response with restricted functionality. However, this observation is based on limited data because low T cell frequencies have hindered effective ex vivo analysis. We adapted the ELISpot assay to over...

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Detalles Bibliográficos
Autores principales: Chua, Conan G., Mehrotra, Aman, Mazzulli, Tony, Wong, David K., Feld, Jordan J., Janssen, Harry L. A., Gehring, Adam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347526/
https://www.ncbi.nlm.nih.gov/pubmed/32647116
http://dx.doi.org/10.1038/s41598-020-68226-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347526/
https://www.ncbi.nlm.nih.gov/pubmed/32647116
http://dx.doi.org/10.1038/s41598-020-68226-5

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